Yuu and Nobu are practicing manzai (a two-person comedy act) act on the roof of the school. At the same time, the school building is overflowing with the presence of non-human "something else." It is said that if a person dies after being bitten by one of them, it will turn into the same "something else" and attack people. In the chaos of the school, Will Yuu, Nobu, and the other surviving students be able to escape from its evil hands?

(Source: Crunchyroll)

Note: A short special edit of the OVA, titled Alice in Deadly School Tokubetsu-ban: Ima, Stage no Maku ga Agaru (Alice in Deadly School Special Edit -The Stage Begins-), was broadcasted on Jan 4, 2021 as part of the New Year's special.